Ondansetron and chemotherapy induced emesis

During the 3rd International Congress on Neoadjuvant§Chemotherapy (Paris 1991) a complete symposium was devoted§to chemically induced nausea and vomiting and to the value§of Ondansetron. This book comprises original articles§dealing with the different topics discussed during this§session. It provides fuller information on current practice§in anti-emetic treatment during anti-cancerous chemotherapy§and sets out the position of a new and important drug,§ondansetron, in this pathology. Different international§clinical studies made with ondansetron in various types of§patients are analysed: specific studies in hematology or in§pulmonary disease, evaluation against benzamide-corticoid as§a combined reference standard, or further the additive§effect of a corticoid combined with ondansetron. One article§is devoted to the use of the drug in children. Finally,§recent programmes dealing with both the intravenous and the§oral use of ondansetron are assessed. The last article deals§with the economic evaluation of the use of ondansetron. Thus§the reader will findhere a recent and uo-to-date review of§the results and possible uses of ondansetron, now the§premier member of the class of 5 HT 3 antagonists, in§chemically induced nausea and vomiting.