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During the last 10-12 years, the research on homocysteine has become very active.About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factorfor pregnancy complications and fetal malformations, cardiovasculardisease, dementia, psychiatric and neurologic disorders and possiblycarcinogenesis. A disturbed homocysteine metabolism can in most cases be normalisedby treatment with folate and/or vitamines B12 and B6. Many of thesefindings therefore directly concern most practitioners.However, if there are good reviews covering single aspects of thisresearch, these are published in specialised journals. The author hasrealised the difficulties for the practitioner in keeping updated.This second edition has been thoroughly updated and also offers moredata on the vitamins. Over 1600 references are made available.