Advances in Enzyme Regulation

Stepping ahead of the general front, Volume 41 in the series "Advances in Enzyme Regulation" moves the studies of mammalian enzymic and metabolic regulation forward. This volume was dedicated on the centenary of his birth to Sir Hans A. Krebs who gave the Special Symposium lectures for 15 years. George Weber spoke on the joint work he carried out in Oxford with Krebs and his associates, entitled 'Cancer and Clinical Targeting.' Much of the Symposium centered on novel aspects of signal transduction, including Inositol Signaling and on phosphatidylinositol 3'kinase and kinase B. The Special Symposium Lecture was given on Inositol Lipid Signaling in the Nucleus. The location and regulation of protein kinases were discussed. Clinical aspects of enzyme regulation were presented featuring studies on dihydrophyrimidine dehydrogenase, development, citrullinemia and human melanoma heparanase. Drug targeting and resistance were reviewed featuring etoposide and tumor vasculature. Regulation of pyruvate dehydrogenase kinase and abrogration of cytokine-dependency were analyzed. Challenging results on mRNA stability and apoptosis were presented covering cyclooxygenase-2 inhibitors, lysosomal cathepsins, human breast tumors and actin reorganization.