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Protein design is the art of choosing an amino acid§sequence that will fold into a §desired structure. Computational protein design aims§to quantify and automate this §process. In computational protein design, various§metrics may be used to calculate an §energy score for a sequence with respect to a desired§protein structure. An ongoing §challenge is to find the lowest-energy sequences from§amongst the vast multitude of §sequence possibilities. A variety of exact and§approximate algorithms may be used in this §search.