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Activation of Silent Biosynthetic Pathways through Co-culture

Language EnglishEnglish
Book Paperback
Book Activation of Silent Biosynthetic Pathways through Co-culture Antonius R B Ola
Libristo code: 05196022
Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG, July 2014
This book is dealing with approaches to activate silent biosynthetic pathways and with the structure... Full description
? points 167 b
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This book is dealing with approaches to activate silent biosynthetic pathways and with the structure elucidation of fungal bioactive natural products focusing mainly on antibiotic and cytotoxic activities. As microbial interactions represent a significant factor for activation of silent biosynthetic pathways, an approach to maximize chemical diversity of endophytic fungi through coculture of fungi and bacteria was undertaken. In addition, inhibitors of histone deacetylases (HDAC) and DNA methyltransferases (DMATs) were also used to induce the secondary metabolite production of endophytic fungi. Moreover, investigation of bioactive metabolites from endophytic fungi under axenic culture conditions led to the isolation of the antibiotic compound neosartorin and of the new atropisomers diaporthemin A and B.

About the book

Full name Activation of Silent Biosynthetic Pathways through Co-culture
Author Antonius R B Ola
Language English
Binding Book - Paperback
Date of issue 2014
Number of pages 128
EAN 9783838138619
ISBN 3838138619
Libristo code 05196022
Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG
Weight 200
Dimensions 152 x 229 x 8

Categories

Mathematics & Science > Chemistry > Organic chemistry
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