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This book provides an insight into all aspects of von Willebrand disease. It describes the important and complex role of von Willebrand factor in haemostasis and thrombosis, in addition to our current understanding of its molecular biology, with a particular focus on the association between genetic variants of von Willebrand factor and these disease phenotypes. It also reviews the important area of the obstetric and gynaecological manifestations of von Willebrand disease, as well as the treatment of urgent bleeding.