Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury

Objective: Present study was designed to investigate effect of gemfibrozil on I/R. Experimental: I/R in rats were induced by bilateral carotid artery occlusion (30 min) and followed by reperfusion (2 hrs). Results and Discussion: Gemfibrozil treated rats demonstrated significant reduction in infarct sizes (P 0.05) when compared with I/R group of rats, suggested that gemfibrozil markedly attenuated I/R injury. Gemfibrozil treatment demonstrated a significant decreased in malondialdehyde (P 0.01), and significant increased was observed in level of reduced glutathione (P 0.01), superoxide dismutase (P 0.05) and catalase (P 0.01). Gemfibrozil treatment resulted significant increased in level of Na+-K+ ATPase (P 0.05) and Mg+2 - ATPase (P 0.01) and significant reduction of Ca+2 - ATPase (P 0.01) when compared with I/R group of rats. Conclusion: In conclusion, gemfibrozil attenuated the cerebral ischemia reperfusion injury and prevention is being shown via membrane stabilization, reducing the oxidative stress, and preventing apoptotic cell death.