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Ribonucleases catalyze the degradation of RNA and form one of the super families of enzymes. This book presents a collection of reviews on the major groups of ribonucleases and gives a comprehensive overview on their structures, mechanisms and functions as well as their role in post-transcriptional regulatory pathways. The detailed knowledge of ribonuclease structure, catalytic mechanism, and interacting partners is spurring new approaches to the treatment of disease. Thus, the book also provides a look at the wider involvement of ribonucleases in cellular pathways, and medical applications.