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All too often ancient herbal and other remedies have been dismissed as "simply" folklore, of no relevance to the medical science of today. John Riddle's approach, however, has been to explore the history of drugs with the hypothesis that ancient and medieval medicines were effective - a methodology that expounds in the final essay (hitherto unpublished). Indeed, he shows, both from detailed case-studies and from the comparison of the listings given by classical and medieval authorities with those in modern pharmacopoeias, that our ancestors had discovered and made effective use of many of the drugs used in medicine today, from antiseptics and analgesics to oral contraceptives, even chemotherapy for cancer. There is the suggestion, therefore, that more careful examination and identification of the drugs used in the past may reveal chemicals that can be exploited anew. Central to these studies is the investigation of how a drug was used and how knowledge about it was transmitted - and perhaps also distorted in the process - from the classical world through the Middle Ages.