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This issue of "Medical Clinics" brings the practicing internist up to date on the latest approaches in psychiatry. This title includes topics such as: collaborative care and consultation, including interviewing, cultural competence, and enhancing rapport and adherence; assessments of the risk of suicide or violence in a patient in crisis; cognitive impairment such as delirium and dementia; dysregulated mood such as major depression and bipolar disorder; anxiety disorders such as panic attacks, generalized anxiety, post-traumatic stress, and obsessions or compulsions; psychopharmacologic care, including antidepressants, antipsychotics, anxiolytics, mood-stabilizing anticonvulsants, and natural remedies; and, non-pharmacological care of patients with co-morbid medical and psychiatric conditions, including different types of psychotherapy of the medically ill. It also includes: substance use and abuse; treating the patient with multiple physical symptoms or chronic disease including somatoform disorders, AIDS, cancer, diabetes, and hypertension; symptoms at the interface of medicine and psychiatry such as pain, sleep disturbance, gastrointestinal distress, sexual dysfunction, premenstrual dysphoria, and grief; informed consent, handling capacity decisions, civil commitment, boundary issues, and malpractice claims; and, an approach to the patient with organ failure, transplantation and end-of-life treatment decisions.