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Patients with two or more risk factors have a very high risk of developing cardiovascular disease. It follows that the strategy for the intervention of multiple risk factors is in fact of paramount relevance in detecting patients at high risk of cardiovascular disease requiring therapeutic intervention. §Multiple Risk Factors in Cardiovascular Disease: Vascular and Organ Protection also discusses risk factors from the point of view of biochemists and pharmacologists by addressing the mechanisms underlying the onset of hypertension, hyperlipoproteinaemia, hypercoagulability, and the possibility of therapeutic intervention. §Audience: Biochemists, pharmacologists and clinical pharmacologists, specialists in the field of cardiovascular medicine seeking to keep abreast of current knowledge in the fast moving field of cardiovascular disease.