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Readers will find information describing the structure of Metallothioneins (MT) family members and cellular functions of MT-1, MT-2 and MT-4 isoforms as well as insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of immune system.