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Aimed at students, practitioners, nutritionists, and food technologists, this text addresses the growing field of metabiotics. Metabiotics are products based on components of cells, metabolites and signaling molecules released by probiotic strains, engineered to optimize host-specific physiological functions in a way that traditional probiotics cannot. This research text will examine the history, processes, comparisons to traditional probiotics, target-specific designs, classifications, and functions of metabiotics, and provide an overview of the composition and function of the gut microbiota. One chapter explores the safety and side-effects of traditional probiotics, and others thoroughly detail the development of target-specific metabiotics. The goal is to provide a complete history and understanding of this new field, likely to be the next phase of the probiotic industry.