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Intricacies of T Cell Activation and Signaling
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138 b
30 dní na vrácení zboží
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T cell signal transduction is not a linear pathway,§but involves multiple components acting as a network.§Though CD8 T cells are capable of being stimulated§with a brief stimulus, recent studies have brought to§focus the persistence of signaling in T cells post§synaptic engagement. Though these signals are not§strong enough for direct detection, their effect on§functional maturity of T cells is ascertained by§functional assays. Different outcomes of activated T§cells do exhibit a certain level of hierarchy in the§order of activation and the strength of signal§required for each. The intracellular signaling§components seem to form modules involved in§persistence of signaling in T cells. This book§provides an overview of T cell activation focusing on§CD8 T cells.
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