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Volume 42 presents an in-depth review on Alzheimer's Disease as well as a look at several transcription factors. Among its key features, it: provides clinical features of stroke and the current stasis of stroke therapy; talks about Alzheimer's Disease - pathology, pathological proteins, etiology, pathogenesis, neurotransmitter alterations, and treatment strategies; presents an examination of the regulation of AP-1 and related transcription factors and their role in brain injury and drug abuse-related behavior; talks about emerging roles of the transcription factor NF (B Recent advances about the nature of alterations in ion channel structure or function which may be responsible for epileptogenesis; presents an integrated model accounting for the multiple mechanisms involved in the posttranslational regulation of glutamate ionotroic receptors; and covers Genetic mutation and the Glycine Receptor.