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The study aimed at observing the hypoglycemic effect of one of the seasonally available highly nutritious leafy vegetable Colocasia esculenta / antiquorum on sixty NIDDM subjects selected from General Hospital, BHEL, Hyderabad,India.The patients were provided with packets of powder every day and were asked to consume along with meal for a period of 3 months. Significant variation in the fasting and post prandial blood glucose levels of Type II diabetic subjects were observed from that of pre-supplementation to the post supplementation periods. Colocasia when supplemented for 3 months to hyperglycemic patients were proved to be effective in reducing the fasting and post prandial blood glucose levels. Colocasia leaves were also proved to be hypocholesterolemic in reducing the higher lipid levels in hypercholesterolemic patients with little or no variation in the levels of other biochemical parameters like serum bilirubin, serum alkaline phosphotase,SGPT,serum uric acid and blood urea.