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Self-esteem is a well-studied construct that has been§associated with a myriad of behavioral,§psychological and physical health outcomes. The§literature suggests that social support,§socioeconomic status (SES), parental factors,§maltreatment and stressful life events may influence§self-esteem level and trajectory. There is also§evidence for a heritable component of self-esteem.§Although no large molecular genetic studies on§self-esteem exist, associated personality trait§neuroticism and related facets depression and anxiety§have been linked to a polymorphism of the serotonin§transporter gene (5HTTLPR). Therefore, the 5HTTLPR§may also be associated with self-esteem. This book§reviews the literature surrounding gene-environment§interactions and examines the effects of known§environmental risk factors in childhood, the 5HTTLPR,§and their interaction on self-esteem in early adulthood.