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This book investigates molecular events that occur in different channels and specialized membrane domains during cell interactions with the external world as well as between cells of the same or different organs. The text addresses the impact of cell and molecular biology, biophysics, and molecular genetics techniques in the study of ion channels. Contributions discuss such topics as the molecular origin of voltage dependence in ion channels, different aspects of calcium-activated K+ channels of large conductance, progress in gap junction tunnels, and the process of exocytosis.