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This study conducted a series of road tests in the §regular fleet operations of a freight shipping §service to better understand the relationship §between vehicle seat design and driver fatigue, §improve two newly proposed objective methods for §evaluating driver fatigue, and provide design §guidelines for evaluating and improving vehicle seat §characteristics in terms of driver fatigue.§§Based on these results, we find that air-inflated §seat cushions have advantages in terms of subjective §measures of comfort, support, and fatigue. We show §that the objective measure aPcrms highlights §characteristic differences between seat cushions, as §the air-inflated seat cushion provides less area in §high pressure regions, thus occluding less blood §flow to tissue in the seated area. This §characteristic difference between seat cushions is §not highlighted by using previously existing §objective measures. This suggests aPcrms is a §useful measure and should be considered when §evaluating the subjective quality of seat cushion §designs under dynamic conditions, such as those §existing in commercial truck driving.