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This book is a collection of original essays focusing on topics in History and Philosophy of Science in broad view. The essays consider the concept of 'mechanism' and the interaction of science and philosophy more generally, bringing together insights from the History of Science and Philosophy in the Early Modern period and the 20th Century. The collection is a festschrift for Peter Machamer, Professor of History & Philosophy of Science at the University of Pittsburgh. The essays treat philosophers that have figured prominently in Peter Machamer's work over the past few decades, such as Galileo, Descartes, and Hobbes, as well as contemporary issues in Philosophy of Science related to perception, explanation, and values. The book is divided into two main sections: Early Modern History and Philosophy, and 20th Century History and Philosophy of Science. In addition to the specific topics addressed in the essays, the general introduction to the volume and the introductions to the two sections focus on general issues of methodology that range across broader issues of method and evidence in History and Philosophy of Science.