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45S5 bioglasses have been successfully used as bone graft materials in dental and orthopedic surgery but its poor mechanical strength limits its used in load-bearing applications, the approaches that has been used to strengthen the bioglass lead to decreased its bioactivity .Objective: Bio glasses with the composition of 45SiO2,24.5 Na2O,6 P2O5 , CaO ( 24.5- X), by varying zirconia content( X= 0,1,3 and 5 wt %) were synthesized via conventional melting technique. The main objective of the this work was to estimate the role of nano-mZrO2 in 45S5 bioglass system and study their effect on of 45S5 bioactive glass.