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Over the last few years, there has been a rapid progress in our understanding of molecular biology. Techniques like genome sequencing combined with large scale analysis of genes and gene-products, have facilitated the transfer of information from wet labs to electronic computers. Adequate representation and analysis of biological data to derive meaningful hypothesis is an active area of research in Computer Science. This book focuses on the representation, and simulation of biochemical reactions at the molecular level, using an emerging computational paradigm known as -calculus. The book provides an adequate background on different methods and tools available for modelling of biochemical systems, to help readers gain a basic understanding of the field. The concepts in the book are supported using various examples and code snippets to implement them. The concepts presented in the book can be especially useful for graduate students and researchers in Theoretical Computer Science who want to venture into the world of biochemical modelling, or anyone else who may be interested in gaining a general idea of the field.