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This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Starting by discussing epidemiological and diagnostic aspects such as the role of vaccination and pathological aspects, the book then goes to examine the role of oncogenomics, proteomics and next generation sequencing in predicting outcomes. With contributions from medical, surgical and radiation oncologists as well as otolaryncologists the chapters then discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the optimal larynx preservation approach and treatment approaches for tumors of unknown primary are discussed among others. Finally the role of immunotherapy in the field is discussed in detail. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by the most internationally acclaimed authors in the field.