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This paper discusses challenges the US intelligence community faces in helping to counter bioterrorism a real and emerging threat that has the potential to cause mass destruction in the United States, It includes background material on a number of issues related to the threat of bioterrorism to help the reader understand why the bioterrorism threat is real, why it may be growing, and why it could potentially inflict mass destruction, As part of this process the paper reviews key factors associated with bioterrorism threat analysis.