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Chlamydia pneumoniae immunology
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Chlamydiae are common pathogens that cause a number§of serious but preventable§diseases in both humans and animals. In the recent§years, Chlamydia pneumoniae has emerged as a major§cause of human respiratory disease and more§importantly, it has been linked to the establishment§and exacerbation of serious chronic diseases§including atherosclerosis and ischaemic heart§disease, multiple sclerosis and reactive arthritis. §§There has been a lot of research into host responses§to chlamydial infections and the development of§immunopathology; but considerable gaps in our§knowledge remain. The work described here aimed to§analyse the early innate immune responses in the lung§following C. pneumoniae infections with a view to§better understanding host-pathogen interactions and§the role of the earliest immune responses in the§establishment of persistence and chronic inflammatory§disease.
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