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This a text for bioengineering students taking a course on cardiovascular solid mechanics or soft tissue biomechanics. The focus of the book is a look at the response of the heart and arteries to mechanical loads from the perspective of nonlinear solid mechanics and one of its primary goals is to introduce basic analytical, experimental, and computational methods together so as to illustrate how these methods can and must be integrated in order to gain a more complete understanding of the biomechanics of the heart and vasculature. Despite the focus on cardiovascular mechanics, the fundamental methods, indeed many of the specific results, are generally applicable to many different soft tissues. Hence, this book can be regarded as a general introduction to soft tissue biomechanics, not just a study of cardiovascular solid mechanics.