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The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. It elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules. It provides a 'must-have' methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research. It offers step-by-step lab instructions, including necessary equipment, from a global research community.