Advances in Prodrugs

Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field.This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools. Highlights chemistry and pharmacology-related aspects, offering a versatile tool for the readers involved in prodrug development and studyDiscusses in depth treatment of several activation mechanisms and applications for disease treatmentsCovers a range of topics from basic contents, design, mechanisms of actions to current applications in drugs