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Adult Stem Cell Therapies: Alternatives to Plasticity
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This book explores alternative explanations of stem cell plasticity. It discusses a presence of potential pluripotent stem cells in adult tissues, paracrine effects of stem cell therapies, involvement of exosomes and microparticles into observed phenomena as well as present current clinical results with adult stem cell therapies in different clinical settings. The field of regenerative medicine is searching for stem cells that can be safely and efficiently employed for regeneration of damaged organs. The concept proposed a few years ago that adult stem cells are plastic and may extensively transdifferentiate into cells from different germ layers lacks solid experimental support. As a result, the concept of stem cell plasticity, or transdifferentiation, has been challenged, and some positive effects of stem cell therapies have been explained by alternative mechanisms. Adult Stem Cell Therapies is an important addition to the Stem Cell Biology and Regenerative Medicine series.
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